1 Probands

  • Note that the measurement of sum and mean is similar, thus only sum is presented.
  • 13 Primary Variables
  • 12 Secondary Variables
  • Adjusted by Age, Sex, Chip, FSIQ (with or without) and then rank-based invserse normalise transformed (RINT).

1.1 Primary Variables

1.1.1 Not Adjusted

knitr::include_graphics("figures/primary_probands_Notadj.png")


Sample Sizes (Levels of phenotypes) are shown.


1.1.2 Adjusted

1.1.2.1 PCs Excluded

knitr::include_graphics("figures/primary_probands_adj.png")


1.1.2.2 PCs Included

knitr::include_graphics("figures/primary_probands_adjAndPCs.png")


1.2 Secondary Variables

1.2.1 Not Adjusted

knitr::include_graphics("figures/secondary_probands_Notadj.png")


Sample Sizes (Levels of phenotypes) are shown.


1.2.2 Adjusted

1.2.2.1 PCs Excluded

knitr::include_graphics("figures/secondary_probands_adj.png")


1.2.2.2 PCs Included

knitr::include_graphics("figures/secondary_probands_adjAndPCs.png")


2 Unaffected Siblings

  • 7 shared phenotypes betwen Probands and Unaffected Siblings
  • 3 Primary Variables
  • 4 Secondary Variables
  • Adjusted by Sex, Chip and then RINT.

2.1 Not Adjusted

knitr::include_graphics("figures/UnaffSibs_shared_Notadj.png")


Sample Sizes (Levels of phenotypes) are shown.


2.2 Adjusted

2.2.1 PCs Excluded

knitr::include_graphics("figures/UnaffSibs_shared_adj.png")


2.2.2 PCs Included

knitr::include_graphics("figures/UnaffSibs_shared_adjAndPCs.png")


3 Probands & Unaffected Siblings

  • 7 shared phenotypes of Probands and Unaffected Siblings
  • show phenotype distribution both separately and combined

3.1 Separated

3.1.1 Raw

knitr::include_graphics("figures/probandsAndunaffSibs_raw.png")


3.1.2 PCs Excluded

3.1.2.1 Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjIQ.png")


3.1.2.2 Not Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjnoIQ.png")


3.1.3 PCs Included

3.1.3.1 Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjIQ_withPCs.png")


3.1.3.2 Not Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjnoIQ_withPCs.png")


3.2 Combined

3.2.1 Raw

knitr::include_graphics("figures/probandsAndunaffSibs_rawII.png")


3.2.2 PCs Excluded

3.2.2.1 Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjIQII.png")


3.2.2.2 Not Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjnoIQII.png")


3.2.3 PCs Included

3.2.3.1 Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjIQII_withPCs.png")


3.2.3.2 Not Fitting IQ

knitr::include_graphics("figures/probandsAndunaffSibs_adjnoIQII_withPCs.png")